Diagnostic Value of Fibrotic Indices in Egyptian Patients with Chronic Hepatitis and Hepatocellular Carcinoma

Mohamed Hussien; Faten Zahran; Hoda El-Emshaty; Mona Samy Gouida; Muhammad Naeem Iqbal

المؤلفون

Mohamed Hussien Mansoura Chest Hospital, Mansoura, Egypt.
Faten Zahran Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Hoda El-Emshaty Gastroenterology Center, Mansoura University, Mansoura, Egypt.
Mona Samy Gouida Mansoura Children Hospital, Mansoura University, Mansoura, Egypt.
Muhammad Naeem Iqbal The School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Pakistan Science Mission (PSM), Noor Kot 51770, Pakistan.

الكلمات المفتاحية:

Chronic Liver Diseases (CLD); HCV; Hepatocellular Carcinoma (HCC); AFP.

الملخص

Cirrhosis and hepatocellular carcinoma (HCC) end-stages of chronic liver diseases (CLD) are leading causes of morbidity and mortality worldwide. The main aetiologies of CLDs are chronic hepatitis C virus (HCV) infection. The aim of this work was to evaluate fibrotic indices APRI and FIB-4 in patients with chronic liver disease (CLD) with HCC, Cirrhosis, and healthy individuals. In the present study, we have investigated 30 Hepatocellular Carcinoma (HCC) patients, from Gastroenterology Center, Mansoura University, compared with 17 cirrhotic patients, and 25 normal healthy individuals as a control group. Laboratory liver fibrosis indices including FIB-4, APRI, and AST/ALT ratio were calculated in Egyptian patients with chronic hepatitis C virus. Results from this study were high APRI and FIB-4 in HCC patients compared with Cirrhosis and Control groups with significance difference (p<0.05). Based on our observation in this study APRI and FIB-4 which representing fibrotic indices have diagnostic value in the assessment of hepatocellular carcinoma.