Synthesis and Characterization of Cu(II) Complex with NSAIDs (Naproxen and Nimesulide) and Tetramethylethylenediamin

Abstract

Two monomeric ternary complexes of (+) -(S)-2-(6-Methoxynaphthalen-2-yl) propanoic acid (Naproxen) and N-(4-Nitro-2-phenoxyphenyl) methanesulfonamide (nimesulide) were prepared by the reaction of CuCl₂?2H₂O and N,N,N',N'-tetramethylethylenediamine (tmen) in the presence of sodium hydroxide. Both complexes were characterized by the elemental combustion analysis, UV-visible and FT–IR spectroscopy, thermal analysis, and single crystal X-ray diffraction. From the crystal structure of complexes, it is evident that each copper (II) ion is six-coordinate and is bonded to chelating tmen. The complexes of copper (II) and TMEDA with Naproxen and Nimesulide were in the ratio 1:2:1. The Complexes were blue in colour and their melting points were recorded as 196 °C and 220 °C respectively. UV- Visible spectra of complexes exhibited three absorptions. The intense absorption band at higher energy was 250 nm and 300nm for both complexes respectively. Both complexes were found to possess antibacterial properties against four strains, including Staphylococcus aureus, Bacillus spizizenii, Escherichia coli, and Klebsiella pneumonia.