Effect of Sodium Selenite on Kidney Function Test of Rabbits

Authors

  • Saman Alam Department of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Saima Masood Department of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Muhammad Naeem Iqbal The School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Pakistan Science Mission (PSM), Noor Kot 51770, Pakistan.
  • Asfa Ashraf Department of Zoology, Lahore College for Women University, Lahore, 54000, Pakistan; Pakistan Science Mission (PSM), Noor Kot 51770, Pakistan.
  • Fakhar-ul-Nisa Yunus Department of Zoology, Lahore College for Women University, Lahore, 54000, Pakistan.
  • Shiwei Xiao The School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Misbah Ahsan Department of Zoology, Govt. Post Graduate Islamia College (W) Cooper Road, Lahore54000, Pakistan.

Keywords:

Rabbits, Serological parameters, Kidney function enzymes test, Creatinine test, Urea test.

Abstract

This study was conducted to evaluate the effect of Sodium Selenite at different dosage levels mixed with water in rabbit. Fifteen rabbits (120 day old) were purchased from Tolinton market, Lahore. They were divided into three groups having three replicas (5 rabbits each). One group was kept as un-medicated control A. While the other Groups such as B and C were medicated with sodium selenite in a single dose at the rate of 2 and 3 mg/kg of body mass mixed in water for 20 days consecutively. Control diet Group “A†received basal diet without any supplementation. Blood samples were collected on 1st, 7th, 14th, 21st and 28th day of dietry treatment from each group. Various serological parameters of kidney functioning enzymes (RFT) such as Creatinine and Urea were determined by using Semi automated Chemistry Analyzer. A significant increase in Creatinine and Urea levels (p<0.05) in rabbits of various treated groups was recorded after applying statistical ANOVA test. The results revealed that Sodium selenite alters the serum creatinine and urea levels by affecting the kidney and cause renal toxicity in rabbits.

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Published

2016-06-13

How to Cite

Alam, S., Masood, S., Iqbal, M. N., Ashraf, A., Yunus, F.- ul-N., Xiao, S., & Ahsan, M. (2016). Effect of Sodium Selenite on Kidney Function Test of Rabbits. PSM Veterinary Research, 1(1), 17–21. Retrieved from https://psmjournals.org/index.php/vetres/article/view/80

Issue

Vol. 1 No. 1 (2016)

Section

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