Chemical Equivalence of Different Brands of Amoxicillin Trihydrate and Its Efficacy against Bacterial Isolates

Authors

  • Rana Adnan Ali Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Muhammad Ashraf Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Muhammad Adil Rasheed Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Aftab Ahmad Anjum Department of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Ahsan Waheed Rathore The Children’s Hospital and The Institute of Child Health, Lahore 54000, Pakistan.
  • Ahmad Bilal Khan The Children’s Hospital and The Institute of Child Health, Lahore 54000, Pakistan.
  • Muhammad Asad Ali Department of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Aqeela Iqbal Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.

Keywords:

Amoxicillin trihydrate, chemical equivalence, HPLC, E. coli, S. aureus and minimum inhibitory concentration.

Abstract

Four brands of Amoxicillin trihydrate (Alomox LA, Amovet LA, Farmox LA and Novamox LA) were processed for chemical equivalence analysis by high performance liquid chromatography (HPLC) and their minimum inhibitory concentrations (MICs) against Staphylococcus aureus and Escherichia coli by micro-dilution method. The content of amoxicillin in each brand was found acceptable by HPLC. The highest content (101.22%) was found in Farmox LA and the lowest content (90.72%) in Amovet LA. The MIC of amoxicillin against S. aureus and E. coli was 0.25µg/mL and 8µg/mL, respectively. E. coli (26.67%) and S. aureus (13.33%) had moderate resistance to amoxicillin. It was concluded that quality of all brands was acceptable and can be used for E. coli and S. aureus infections due to moderate resistance.

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Published

2016-07-31

How to Cite

Ali, R. A., Ashraf, M., Rasheed, M. A., Anjum, A. A., Rathore, A. W., Khan, A. B., Ali, M. A., & Iqbal, A. (2016). Chemical Equivalence of Different Brands of Amoxicillin Trihydrate and Its Efficacy against Bacterial Isolates. PSM Microbiology, 1(1), 45–49. Retrieved from https://psmjournals.org/index.php/microbiol/article/view/100

Issue

Vol. 1 No. 1 (2016)

Section

Articles

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