Therapeutic Efficacy of Cissus rotundifolia as Antiurolithiasis and Antihypertensive Agent in Albino Rats

Authors

  • Hussein S. Gumaih Faculty of Science, Sana'a University, Sana'a, Yemen.
  • Elsayed N. Salamah Zagazig University, Egypt.
  • Abdulrhman A. Almadiy Faculty of Science and Arts, Najran University, Saudi Arabia.
  • Maher A. AL-Maktari Faculty of Science, Sana'a University, Sana'a, Yemen.
  • Afarah A. AL-Asbahy Taiz University, Yemen.

Keywords:

Cissus rotundifolia; antiurolithiatic; antihypertensive; antioxidant.

Abstract

The present work was undertaken to evaluate the efficacy of the methanolic leaves extract of Cissus rotundifolia, as an anti-urolithic and antihypertensive agent in albino rats by measuring the biochemical parameters, enzyme immunoassay, and free radical scavenging activity using DPPH assay. Twenty four male albino rats were divided into 4 groups (n = 6) as G1 (negative control) received a normal diet, G2 (positive control) received EG (0.75%) and 1% aluminum chloride; G3 was given 200 mg/kg of CR extract daily via a gastric tube for 28 days, G4 was orally given 400 mg/kg of CR extract for 28 days. All the tested samples showed a significant antioxidant DPPH radical scavenging activity in doses of 200 and 400 mg/kg, b.w. A notifiable decrease in serum urea and creatinine levels were also, observed. The present study emphasizes the safe herbal remedies of C. rotundifolia as anti-hypertensive and antioxidants as well as anti-urolithiatic.

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Published

2020-11-30

How to Cite

Gumaih, H. S., Salamah, E. N., Almadiy, A. A., AL-Maktari, M. A., & AL-Asbahy, A. A. (2020). Therapeutic Efficacy of Cissus rotundifolia as Antiurolithiasis and Antihypertensive Agent in Albino Rats. International Journal of Nanotechnology and Allied Sciences, 4(2), 30–40. Retrieved from https://psmjournals.org/index.php/ijnas/article/view/503

Issue

Vol. 4 No. 2 (2020)

Section

Articles

License

Copyright (c) 2020 PSM

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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