Therapeutic Efficacy of Cissus rotundifolia as Antiurolithiasis and Antihypertensive Agent in Albino Rats

Abstract

The present work was undertaken to evaluate the efficacy of the methanolic leaves extract of Cissus rotundifolia, as an anti-urolithic and antihypertensive agent in albino rats by measuring the biochemical parameters, enzyme immunoassay, and free radical scavenging activity using DPPH assay. Twenty four male albino rats were divided into 4 groups (n = 6) as G1 (negative control) received a normal diet, G2 (positive control) received EG (0.75%) and 1% aluminum chloride; G3 was given 200 mg/kg of CR extract daily via a gastric tube for 28 days, G4 was orally given 400 mg/kg of CR extract for 28 days. All the tested samples showed a significant antioxidant DPPH radical scavenging activity in doses of 200 and 400 mg/kg, b.w. A notifiable decrease in serum urea and creatinine levels were also, observed. The present study emphasizes the safe herbal remedies of C. rotundifolia as anti-hypertensive and antioxidants as well as anti-urolithiatic.