Lead Toxicity and Evaluation of Oxidative Stress in Humans

Abstract

Lead toxicity and oxidative stress caused by lead poisoning were studied in control and lead exposure subjects in the Faisalabad population. The study was conducted to investigate the relationship between total oxidant status and serum glucose, triglyceride, LDL-cholesterol, globulin, HDL-cholesterol and total protein, alanine aminotransferase, aspartate aminotransferase and triiodothyronine (T3). In the present study, 25 control and 25 lead exposed subjects were studied. Serum samples were collected from control and lead exposed workers to determine glucose, triglycerides, LDL-cholesterol, globulin, HDL-cholesterol, total protein, alanine aminotransferase, aspartate aminotransferase, Thyroxine (T3) and serum total oxidant status by using respective kits and biochemical methods. The results showed that serum total oxidation status (TOS) was closely related to glucose, triglyceride, LDL-cholesterol and negatively correlated with globulin, HDL-cholesterol and total protein. There was also a positive correlation between total oxidative stress (TOS) and serum alanine aminotransferase and aspartate aminotransferase. There was no positive or negative correlation between total oxidative stress (TOS) and triiodothyronine (T3). Lead concentration was determined by Atomic Absorption Spectrometer, a relatively low concentration of lead was found in control subjects than lead exposed workers. It was concluded that total oxidant status (TOS) was positively correlated with some serum components and negatively correlated with others. But there was no positive or negative association of total oxidative stress (TOS) with Triiodothyronine.